English
क्षमा करें, यह समाचार आपके अनुरोध की भाषा में उपलब्ध नहीं है। कृपया यहाँ देखें।
Have you too wondered if there is any way how you increase your life? If yes, find your answer here.
If you want to live longer, boost your health, reduce inflammation in your body, then eating less may be the solution for you.
While the benefits of caloric restriction have been known for very long, this new study conducted by researchers from US and China show how this restriction can protect against ageing in cellular pathways.
Study’s senior author Juan Carlos Izpisua Belmonte said, “We already knew that calorie restriction increases life span, but now we’ve shown all the changes that occur at a single-cell level to cause that.”
“This gives us targets that we may eventually be able to act on with drugs to treat ageing in humans,” Belmonte added.
The research was based on the study of rats. For the findings, the research team compared rats who ate 30 per cent fewer calories with rats on normal diets.
The diet of animals in the age group of 18-27 months was controlled. (In humans, this would be roughly equivalent to someone following a calorie-restricted diet from the age of 50 to 70.)
The research team isolated and analysed a total of 168,703 cells from 40 cell types in the 56 rats from starting as well as during the conclusion of the diet. The cells came from fat tissues, liver, kidney, aorta, skin, bone marrow, brain and muscle.
In each isolated cell, the researchers used single-cell genetic-sequencing technology to measure the activity levels of genes. Along with this, they also looked at the overall composition of cell types within any given tissue. Then, they compared old and young mice on each diet.
Many of the changes that occurred as rats on the normal diet grew older didn’t occur in rats on a restricted diet; even in old age, many of the tissues and cells of animals on the diet closely resembled those of young rats.
In a nut shell, 57 per cent of the age-related changes in cell composition seen in the tissues of rats on a normal diet were not present in the rats on the calorie restricted diet.
Study researcher Guang-Hui Liu said, “This approach not only told us the effect of calorie restriction on these cell types, but also provided the most complete and detailed study of what happens at a single-cell level during ageing.”
According to the study, some of the cells and genes most affected by the diet related to immunity, inflammation and lipid metabolism.
The number of immune cells in nearly every tissue studied dramatically increased as control rats aged but was not affected by age in rats with restricted calories.
Therefore it can be concluded that, a restricted diet can help retain cells akin to the young ones even in old age.
